Dynamics of alpha helix formation in the CSAW model

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Dynamics of alpha helix formation in the CSAW model.

We study the folding dynamics of polyalanine (Ala20), a protein fragment with 20 residues whose native state is a single alpha helix. We use the CSAW model (conditioned self-avoiding walk), which treats the protein molecule as a chain in Brownian motion, with interactions that include hydrophobic force and internal hydrogen bonding. We find that large-scale structures form before small-scale st...

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ژورنال

عنوان ژورنال: The European Physical Journal E

سال: 2008

ISSN: 1292-8941,1292-895X

DOI: 10.1140/epje/i2007-10371-4